Proton Pump Inhibitors (PPI)

Nexium, Prilosec, Dexilant, Prevacid, Protonix, AciPhex and Zegerid are a class of drugs called proton pump inhibitors (PPIs) that are widely prescribed to treat heartburn, acid reflux and gastroesophageal reflux disease (GERD) in millions of Americans. Research published in the Journal of the American Medical Association (JAMA) in January 2016 shows that those taking PPIs once daily had a 15 percent increased risk of chronic kidney disease and twice-a-day users were 46 percent more likely to develop chronic kidney disease. The study also found that those who took PPIs had a 39 percent higher risk of kidney disease than patients who took H2 blockers, a different type of drug used to treat heartburn and acid reflux. In another study published in the Journal of the American Society of Nephrology, the risk of end-stage renal disease was 96 percent higher in those who took PPIs.

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